Perbandingan Nilai Agregasi Trombosit pada Pasien Diabetes Melitus Tipe 2 dengan Komplikasi Vaskular dan tanpa Komplikasi Vaskular di Rsup Prof. Dr. R. D Kandou Manado

摘要

: Diabetes melitus is a main medical problem around the world. WHO estimated that in 2000 there were 171 milion people with diabetes around the world and in 2030 there will be 366 million people. In diabetic patients, there are dysfunctions of platelet function caused microangiopati, macroangiopati, and platelet reactivity. Dysfunction of platelet function are associated with vascular complications of diabetes melitus. This study used an observational analytic method using comparative hypothesis test. This study was conducted to 30 diabetic patients, 15 patients have vascular complications while the other 15 have no vascular complications. Those patients are registered in Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. The samples were processed in Prokita Laboratorium in Malalayang, Manado. Data analysis showed that there are significant difference between platelet aggregation value examined using ADP 5 µm agonist in diabetic patient with vascular complications and diabetic patients without vascular compications (p = 0.004). The same result were obtained from comparing the platelet agggregation value examined using ADP 10 µm agonist (p = 0.000). There are significant difference between platelet aggregation value in type 2 diabetes melitus patients with vascular complications and without complications.